N5511

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N5511

Fluka

 

(−)-Nicotine solution

drug standard, 1.0 mg/mL±5% in methanol

CAS Number:54-11-5
Beilstein Registry Number:5733110
MDL number:MFCD00006369
PubChem Substance ID:24897737

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Properties

gradedrug standard
concentration1.0 mg/mL±5% in methanol
Gene Informationhuman ... CHRNA3(1136), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
 rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
 mouse ... Chrna7(11441), Chrnb1(11443)
storage temp.2-8°C

Safety

Hazard CodesF,T+
Risk Statements11-23/25-27-39/23/24/25-52/53
Safety Statements7-16-36/37-45
RIDADRUN 1992 3/PG 2
WGK Germany3

References

referenceSihver, W., et al., Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Neuroscience 94, 685-696, (1999)
 Girod, R., et al., Heteromeric complexes of α5 and/or α7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation. Ann. N.Y. Acad. Sci. 868, 578-590, (1999) Abstract
 Brioni, J.D., et al., The pharmacology of (−)-nicotine and novel cholinergic channel modulators. Adv. Pharmacol. 37, 153-214, (1997) Abstract
 Lena, C., and Changeux, J.P., Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr. Opin. Neurobiol. 7, 674-682, (1997) Abstract
 Haass, M., and Kubler, W., Nicotine and sympathetic neurotransmission. Cardiovasc. Drugs Ther. 10, 657-665, (1997)